On November 28, 2023, at a meeting of the Scientific Council of the National Medical Research Center of Hematology, Professor G.Th. Guria made a presentation “Mechanisms of platelet hemostasis. Development of methods for rapid assessment of the risks of intravascular thrombus formation in blood circulation systems.”

Video on the topic “Physics. What is blood from the point of view of physics” was released on radio “Mayak” in the show-program “Physics and Lyrics”.
Invited guest: Prof. Dr. Geogry Th. Guria. Radio broadcast date - October 31, 2022.

Video (In Russian): https://smotrim.ru/video/2504996

Here are the computational results for the mathematical model of platelet activation in a 2D-model of a large artery with stenosis.

The computational results for the mathematical model of platelet activation in arteriovenous fistula for hemodialysis are shown. A simplified 3D-model of the fistula with severe stenosis was used.

Computer reconstruction of scenarios with thrombosis of the coronary arteries as a result of the entry of activated platelets into the coronary blood flow.

The video shows a scenario of the development of blood plasma coagulation in the experimental in vitro system consisting of silicone tubes. Fibre-like fibrin structures floating in the stream are clearly visible.

The video shows the scheme for providing high-tech medical care and assessing the risks of thrombotic complications.

Computer reconstruction for the process of shear-induced platelet activation in a personalized stenotic aorta is shown.

The videos show the results of mathematical modeling of intravascular blood coagulation under wall shear stress. Three activation scenarios were identified for a model of artery with stenosis.

The video shows a scenario of the rapid blood plasma coagulation under intensive blood flow. Over a time of about ten minutes the macroscopic thrombus completely blocks the lumen of the in vitro model of the vessel.

In the process of blood coagulation under blood flow conditions, jelly-like clots resembling fibrin gel may be formed in a number of cases. The results obtained in vitro are consistent with clinical observations in patients with blood coagulation system disorders.

To compare the observations of processes of blood coagulation in vitro with the processes taking place in the cardiovascular system, the records of real ultrasound studies of the vessels were analyzed.

The videos show the spatio-temporal dynamics of the velocity modulus and the volumetric shear rate in a stenosed arteriovenous fistula for hemodialysis.

The video shows the results of computer reconstruction for the process of shear-induced platelet activation in a personalized brachial arteriovenous fistula.

The videos show the results of mathematical modeling of platelet activation processes in the modeled device for auxiliary blood circulation FDA Blood Pump.

The video materials on the study of the operation of the BIOPUMP centrifugal pump for auxiliary circulation on a test bench with blood plasma.

Polymeric vessels designed for in vitro experiments on the study of patient-specific features of the blood coagulation system and hemodynamics.

Here is a typical scenario of the rapid formation of large thrombs that occur in the flow for a few minutes.