Project "in silico"

Assesment of thrombosis risks, based on computer modelling with broad validation:


Global list of 35 young innovators awarded by MIT Technology Review organization.
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June 26, 2019

The Russian TV channel «Russia-Cultura» released a video concerning the research conducted in the laboratory.
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April 26, 2019

The publication in PLOS ONE (Ivlev et al, 2019) received a response in a number of mass media and Internet resources.
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April 17, 2019


Welcome to the laboratory of Georgy Th. Guria

Our team consists of the researchers, working along with Prof. Georgy Guria on the study of the role of instabilities in the dynamics of complex systems, including biological regulation.

It is generally accepted that the loss of stability of any regime is a prologue to the transition of that nonequilibrium system to another state having a different time or space-time ordering. The study of different types of such non-equilibrium transitions observed in the physico-chemical and biological systems, and the task of revealing the conditions for the implementation of such transitions is the main subject of the research of our team.

Diagram Graph Signals

At the moment, obviously the most attention is given to transitions manifested in the dynamics of such sophisticated physiological substance as blood [Thrombosis Research, 2015; Guria, 2011]. In the center of our attention are both theoretical issues of finding conditions of loss of the liquid state stability of the blood, and questions concerning the development of tools and methods for real-time monitoring of aggregate state of blood in vitro and in vivo [Scientific Reports, 2016; PLOS ONE, 2015; JTB, 2012; PLOS ONE, 2019; PhilosTrans, 2008]. The laboratory team uses and enhances the research approach in silico, aimed at the task of personalized assessment of thrombosis risks through the use of modern computer simulation methods (more on

Recently, particular attention is paid to finding opportunities of a fast-reacting medical interference during the fastest flowing phase of intravascular thrombosis. [PLOS ONE, 2019; PhilosTrans, 2008].

The range of actively studied systems is not limited to blood coagulation system. Among the actively studied issues are mass transfer processes in the human body and the work of the cellular signaling system.


Our research has been funded by the Russian Foundation for Basic Research (RFBR), the International Science and Technology Center (ISTC), the Russian Science Foundation (RSF).

Student positions:

We are looking for highly motivated individuals to join our laboratory at every level – as undergraduate researchers, MS or PhD students. Positions are available immediately. Please contact Prof. Georgy Guria for more information.