Projects

Ultrasound technique for the study of blood coagulation system:

We are using ultrasound technique for the study of coagulation and fibrinolysis phenomena in our original experimental set-up. In particular this set-up allows us to analyze the physiological effect of the existing pharmaceutical drugs.

This research direction has been supported by grants of the Russian Foundation for Basic Research:
- N 14-04-01193 (2014-2016), «Исследование влияния условий формирования тромба на его резистентность к действию фибринолитических агентов»;
- N 07-04-01523-a (2007-2009), «Исследование спонтанного тромбообразования в интенсивных потоках»;
- N 04-04-49423-a (2004-2006), «Акустические эффекты при свертывании крови в интенсивных потоках».

Two demonstrations of the blood coagulation are shown below in the movies:

On the left you may see the typical scenario of a rapid formation of large thrombs occurring in the flow for a few minutes.

At the bottom you may see both the information from the ultrasound detector (right) and the optical channel (left). This video demonstrates the formation of fibrin thread during the coagulation of blood plasma.

The details concerning the experimental set-up, materials and methods you may find in the paper: [Uzlova et al., Acoustic determination of early stages of intravascular blood coagulation // PhilosTrans, 2008].

Personalized maps of potential thrombogenic danger:

Another research direction is the development of unique software and hardware complex, allowing to build personalized maps of potential thrombogenic danger for different areas of cardiovascular system of individual patients, and also to produce video material, which illustrates possible activation scenarios of intravascular coagulation processes. Creation of maps of potential thrombogenic danger will open new possibilities not only for doctors but also for patients to evaluate a priori, more fully and deeply the structure of the actual risks of the development of extremely dangerous pathologies associated with cardiac and cerebral circulation disorders.

Here you can look at the test page of the access to the program compex and scenarios of thrombodynamics:
link.

This research direction has been broadly funded by various grants:
- Russian Science Foundation (RSF) N 14-14-00990 (2014-2016), «Mathematical modeling of blood coagulation phenomena in human cardiovascular system»;
- International Science and Technology Center (ISTC) N 3744 (2007-2010), «Computational Modeling of Blood Hydrodynamics and Aggregation Phenomena in the Human Cardiovascular System»;
- Russian Foundation for Basic Research (RFBR): N 99-04-48759-a (1999-2001), «Роль нестабильностей в динамике крови»; N 99-01-01145-a (1999-2001), «Математическое моделирование тромбообразования в сосудах сложной геометрии с использованием моделей неньютоновских жидкостей»; N 96-01-01306 (1996-1997), «Численное исследование неравновесных диссипативных структур в моделях тромбообразования».